SVN-SDN-14

About SVN-SDN-14

A series of serotonin, dopamine and noradrenaline modulators under pre-clinical investigation by Solvonis. They are being assessed for potential to promote pro-social behaviour and offer an improved safety profile compared to existing treatments being developed for post-traumatic stress disorder (PTSD).

Pro-social behaviour is increasingly recognised as a key factor in addressing PTSD. Enhancing these behaviours may help individuals with PTSD overcome feelings of isolation, rebuild interpersonal relationships and engage more effectively in therapeutic interventions.

Intellectual property

Composition of matter patents filed internationally by Solvonis.

Mechanism of action

Novel monoaminergic modulator targeting SERT, DAT, and NET transporters.

Designed to rebalance dysregulated neurotransmission in PTSD-relevant circuits.

Progress to date

Patents filed covering novel chemical matter.

Hit-to-Lead completed with multiple compounds advanced.

In vitro and in vivo efficacy signals demonstrated.

Status and pathway

2026(f): Lead identified

2028(f): IND-enabling studies.

2029(f): IND submission.