Solvonis Therapeutics
LSE: SVNS

A clinical-stage psychedelics company developing therapeutics for addiction, PTSD and depression

An alcohol use disorder franchise across the UK, Europe and the U.S. A de novo engine of proprietary new medicines.

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Strategy

Two complementary development strategies

Scientific leadership: Professor David Nutt, Chief Scientific Officer, and Edmond J Safra Professor of Neuropsychopharmacology at Imperial College London.

Value-added medicines: the AUD franchise

Differentiated ketamine- and esketamine-based treatments built on established pharmacology, clinical experience and regulatory precedent.

SVN-001 | Phase 3 in severe alcohol use disorder (AUD) in the UK; EU sites proposed
SVN-002 | Esketamine oral thin film (OTF) with an FDA-agreed 505(b)(2) route and a scientific bridge to SPRAVATO®; Phase 2b planning in moderate-to-severe AUD (U.S.)

Value creation | Nearer-term clinical and regulatory catalysts

De novo drug development: the engine

Creating proprietary new chemical entities (NCEs) with composition-of-matter filings in high-burden addiction and psychiatric disorders.

SVN-015 StUD | A new stimulant use disorder candidate; encouraging initial NIDA-funded screening, advanced into further NIDA-funded studies
SVN-114 | A preclinical entactogen for PTSD
SVN-015 MDD | Depression with anhedonia

Value creation | Longer-duration IP and early-stage upside

Supported by U.S. federal, UK government and academic partners

The SVN-001 Phase 3 is co-funded by the National Institute for Health and Care Research (NIHR), the Medical Research Council (MRC) and Solvonis, and sponsored by the University of Exeter. The U.S. National Institute on Drug Abuse (NIDA) funds the SVN-015 evaluation, which has advanced into further NIDA-funded studies.

Pipeline

Five programmes: an alcohol use disorder franchise and a de novo engine

AUD franchise
De novo engine
Programme
Indication
Status
SVN-001
Severe AUD | UK (EU sites proposed)
Ongoing UK Phase 3; MoU signed to assess Portuguese sites
SVN-002
Moderate-to-severe AUD | U.S.
Phase 2b planning
SVN-015 StUD
Stimulant use disorder (StUD)
Encouraging initial NIDA-funded screening (Aug 2026); advanced into further NIDA-funded studies
SVN-114
PTSD
Lead selected
SVN-015 MDD
Depression with anhedonia (MDD)
Preclinical; antidepressant-like signal in rodent model

See the full pipeline

SVN-001, SVN-002, SVN-015 and SVN-114 are investigational. None has been approved by any regulator, and their safety and efficacy have not been established.

Why addiction, and why now
12.5m

people aged 15+ with severe AUD in the UK and EU4 (Company estimate)

11.3m

people aged 12+ with past-year moderate-to-severe AUD in the U.S. (2024)

1 in 6

people with AUD worldwide receive treatment

59%

of U.S. overdose deaths (2021 to mid-2024) involved stimulants

Epidemiological estimates, not treated or addressable patients. UK and EU4 (France, Germany, Italy, Spain) figure is a Company estimate (July 2026); U.S. figure: SAMHSA, 2024 NSDUH. Treatment rate: Mekonen et al., Addiction 2021. Stimulants: Tanz et al., MMWR 2025.

Sector context

Pharma is paying for psychedelic and rapid-acting neuropsychiatry assets

SEP 2026
Eli Lilly / AtaiBeckley
$2.8bn + up to $1.0bn
Psychedelic-derived therapies; lead in depression
JUN 2026
Otsuka / Transcend
$700m + up to $525m
Methylone; Phase 3 PTSD asset
OCT 2025
AbbVie / Gilgamesh
up to $1.2bn
Bretisilocin; Phase 2 MDD asset

Pharma has paid billions for depression and PTSD. Solvonis has programmes in both, and a Phase 3 ketamine-based treatment in alcohol use disorder (AUD), where only 1 in 6 people receive treatment.

Sources: Eli Lilly, 11 September 2026 (completion) and 16 July 2026 (terms); Otsuka, 12 June 2026; AbbVie, 17 October 2025. Values include contingent consideration where stated. Dates are completion dates. Sector context; not valuation comparables.

Latest news

All news
13 Oct 2026Solvonis and Portugal’s National Addiction Institute sign an MoU to advance planned European expansion of SVN-001 Phase 3 trial 29 Sep 2026SVN-001 Ahead of Established and Emerging AUD Treatments 3 Sep 2026Vital Patent milestone achieved – SVN 114 25 Aug 2026Solvonis Raises £1.3 Million
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